WebbOptimal Two-Stage Designs For Phase II Clinical Trials Richard Simon, Controlled Clinical Trials 10:1-10, 1989. Enter probability of accepting poor drug (alpha) [between 0 and 0.3 … Webb1 jan. 2002 · The optimal two-stage design was proposed by Simon. This method determines the adequate sample size by calculating the response probability of two groups with α and β errors [1, 2]....
A new adaptive design based on Simon
WebbAn optimal stratified Simon two-stage design In Phase II oncology trials, therapies are increasingly being evaluated for their effectiveness in specific populations of interest. … WebbThis paper presents two-stage designs that are optimal in the sense that the expected sample size is minimized if the regimen has low activity subject to constraints upon the … sf8g6 thk
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Webb28 juli 2024 · Since Rich Simon proposed optimal design and minimax design for two-stage phase II trials in 1986, either of them has been chosen for most of phase II clinical … Webb1 mars 1989 · BRCA1/2-related metastatic breast cancers (mBC) are sensitive to DNA-damage agents and show high tumor-infiltrated lymphocytes.We hypothesized that the … Webb• Gehan 2-Stage • Simon 2-Stage Optimal • Simon 2-Stage Minimax • Fleming 1-stage • Gehan-Simon 3-Stage • Randomized Phase 2 • Constant Arc-Sine • Randomized ... Two-stage design with early stopping rule for efficacy or futility. 7 Endpoints • Primary • Secondary • Direct • Surrogate Primary & Secondary Endpoints sf 91 usmc form